HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Twenty-four-hour secretory patterns of gonadotropins and prolactin in a case of Chiari-Frommel syndrome.

Abstract
Plasma LH, FSH and prolactin secretory patterns were derived from the measurement of 20-min interval plasma samples obtained during a complete 24-h period in a patient with persistent postpartum amenorrhea and galactorrhea (Chiari-Frommel syndrome), before and after clomiphene citrate therapy. During nocturnal sleep, polygraphic monitoring was carried out to precisely identify sleep onset, specific sleep stages and waking periods. During the evening and nighttime hours, LH and FSH concentrations were markedly reduced, compared to the daytime patterns both before and after clomiphene therapy. A sleep associated rise of prolactin concentration was present, similar to the pattern found in normal subjects but at higher concentrations. The reciprocal nature of the nocturnal secretory patterns for LH and FSH and prolactin in this patient suggests an alteration in hypothalamic dopaminergic mechanisms which are thougt to control the secretion of these hormones.
AuthorsS Kapen, R Boyar, R Freeman, A Frantz, L Hellman, E D Weitzman
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 40 Issue 2 Pg. 234-9 (Feb 1975) ISSN: 0021-972X [Print] UNITED STATES
PMID1167938 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Clomiphene
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Adult
  • Amenorrhea (etiology)
  • Chiari-Frommel Syndrome (blood, drug therapy)
  • Circadian Rhythm
  • Clomiphene (therapeutic use)
  • Female
  • Follicle Stimulating Hormone (secretion)
  • Galactorrhea (etiology)
  • Humans
  • Luteinizing Hormone (secretion)
  • Pregnancy
  • Prolactin (secretion)
  • Sleep

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: