Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: successful treatment with allogeneic bone marrow transplant.

Abstract

OBJECTIVE:

and importance Therapy-related myelodysplastic syndrome (t-MDS) is a rare and typically fatal complication of therapy for cancer, including brain tumors. We report successful therapy of t-MDS that developed after treatment for an anaplastic astrocytoma.

CLINICAL PRESENTATION:

t-MDS developed four and one-half years after successful therapy (resection, radiation and chemotherapy) administered for a cerebral anaplastic astrocytoma in a 34-year-old patient.

INTERVENTION:

The patient was treated with allogeneic bone marrow transplant (BMT) for t-MDS.

CONCLUSION:

She is alive three years after BMT with no evidence of brain tumor and in complete remission from t-MDS. To our knowledge, this is the first report of allogeneic BMT administered for t-MDS in an adult brain tumor patient. Clinicians must be alert to the development of t-MDS following chemotherapy for brain tumors and initiate appropriate treatment promptly.

• Authors: L R Rogers, N Janakiraman, C Kasten-Sportes, M L Rosenblum
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 53 Issue 1 Pg. 55-9 (May 2001) ISSN: 0167-594X [Print] United States
• PMID: 11678432 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Adult
• Anemia, Refractory, with Excess of Blasts (chemically induced, therapy)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Astrocytoma (therapy)
• Bone Marrow Transplantation
• Brain Neoplasms (therapy)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Middle Aged
• Radiotherapy, Adjuvant
• Transplantation, Homologous