Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity.

Abstract

Activities of adenosine deaminase (ADA), adenosine kinase (AK), adenine phosphoribosyltransferase (APRT), hypoxanthine guanine phosphoribosyltransferase (HGPRT), and purine nucleoside phosphorylase (PNP), all enzymes of the purine interconversion system, were determined in lymphocytes of 25 patients with chronic lymphatic leukemia (CLL) and in 23 controls. A statistically significant decrease of PNP activities and a reduction of ADA activities at borderline levels were found in the patients, whereas for the other enzymes assayed no deviation from normal values was observed.

• Authors: H Ludwig, R Kuzmits, H Pietschmann, M M Müller
• Journal: Blut (Blut) Vol. 39 Issue 5 Pg. 309-15 (Nov 1979) ISSN: 0006-5242 [Print] Germany
• PMID: 116697 (Publication Type: Journal Article)

Chemical References

• Pentosyltransferases
• Purine-Nucleoside Phosphorylase
• Adenine Phosphoribosyltransferase
• Hypoxanthine Phosphoribosyltransferase
• Adenosine Kinase
• Nucleoside Deaminases
• Adenosine Deaminase

Topics

• Adenine Phosphoribosyltransferase (blood)
• Adenosine Deaminase (blood)
• Adenosine Kinase (blood)
• Aged
• Female
• Humans
• Hypoxanthine Phosphoribosyltransferase (blood)
• Leukemia, Lymphoid (enzymology)
• Male
• Middle Aged
• Nucleoside Deaminases (blood)
• Pentosyltransferases (blood)
• Purine-Nucleoside Phosphorylase (blood)