Predominance of oligoclonal IgG type lambda in CSF in aseptic meningitis.

Abstract

Oligoclonal immunoglobulins (Ig) demonstrble as bands by agarose-gel electrophoresis of CSF were characterized in ten patients with aseptic meningitis. Oligoclonal CSF IgG was found in all patients, IgM was found in two. The oligoclonal Ig was more often of lambda light-chain type than of kappa type. In four patients, oligoclonal Ig bands contained kappa and lambda light chains simultaneously. In two patients, bands consisting of free lambda light chains were found. On repeated investigations more than one year later in three cases, the oligoclonal IgG was of the same light-chain type. The immune response within the CNS in aseptic meningitis seems to be dominated by synthesis of IgG with lambda light chains.

• Authors: A Frydén, H Link
• Journal: Archives of neurology (Arch Neurol) Vol. 36 Issue 8 Pg. 478-80 (Aug 1979) ISSN: 0003-9942 [Print] United States
• PMID: 116631 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin G
• Immunoglobulin Light Chains
• Immunoglobulin kappa-Chains
• Immunoglobulin lambda-Chains

Topics

• Adolescent
• Adult
• Humans
• Immunoglobulin G (cerebrospinal fluid)
• Immunoglobulin Light Chains (cerebrospinal fluid)
• Immunoglobulin kappa-Chains (cerebrospinal fluid)
• Immunoglobulin lambda-Chains (cerebrospinal fluid)
• Meningitis (cerebrospinal fluid)
• Meningitis, Aseptic (cerebrospinal fluid)
• Middle Aged