Perinatal factors associated with severe intracranial hemorrhage.

The purpose of this study was to assess the incidence of perinatal factors that are associated with severe intracranial hemorrhage in a large and recent multicenter experience.
Retrospective analyses of nonanomalous newborns who were admitted to 100 neonatal intensive care units from 23 to 34 6/7 weeks' gestation were analyzed by multiple regression.
There were 12,578 premature newborns with a mean (+/- SD) gestational age of 31.3 +/- 2.9 weeks and a birth weight of 1685 +/- 571 g, respectively. The overall incidence of severe intracranial hemorrhage was 2.9%; in 4575 newborns who weighed < or = 1500 g the incidences of intracranial hemorrhage was 7.1%. Factors with positive and negative associations with severe intracranial hemorrhage are listed in order of decreasing statistical significance: gestational age (negative), surfactant (positive), antenatal indomethacin (positive), neonatal transport (positive), cesarean birth (negative), poor prenatal care (positive), 5-minute Apgar score of < 7 (positive), chorioamnionitis (positive), antenatal terbutaline (negative), preterm premature rupture of fetal membranes (negative), and abruption (positive).
The incidence of severe intracranial hemorrhage has dramatically declined over the past 2 decades. Antenatal steroids were not associated with reductions in severe intracranial hemorrhage.
AuthorsJ A Thorp, P G Jones, R H Clark, E Knox, J L Peabody
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 185 Issue 4 Pg. 859-62 (Oct 2001) ISSN: 0002-9378 [Print] United States
PMID11641666 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
  • Birth Weight
  • Cerebral Hemorrhage (diagnosis, epidemiology)
  • Cesarean Section
  • Confidence Intervals
  • Female
  • Gestational Age
  • Humans
  • Incidence
  • Infant Mortality (trends)
  • Infant, Newborn
  • Infant, Premature
  • Intensive Care Units, Neonatal
  • Logistic Models
  • Odds Ratio
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index

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