Abstract | OBJECTIVE: The purpose of this study was to assess the incidence of perinatal factors that are associated with severe intracranial hemorrhage in a large and recent multicenter experience. STUDY DESIGN: Retrospective analyses of nonanomalous newborns who were admitted to 100 neonatal intensive care units from 23 to 34 6/7 weeks' gestation were analyzed by multiple regression. RESULTS: There were 12,578 premature newborns with a mean (+/- SD) gestational age of 31.3 +/- 2.9 weeks and a birth weight of 1685 +/- 571 g, respectively. The overall incidence of severe intracranial hemorrhage was 2.9%; in 4575 newborns who weighed < or = 1500 g the incidences of intracranial hemorrhage was 7.1%. Factors with positive and negative associations with severe intracranial hemorrhage are listed in order of decreasing statistical significance: gestational age (negative), surfactant (positive), antenatal indomethacin (positive), neonatal transport (positive), cesarean birth (negative), poor prenatal care (positive), 5-minute Apgar score of < 7 (positive), chorioamnionitis (positive), antenatal terbutaline (negative), preterm premature rupture of fetal membranes (negative), and abruption (positive). CONCLUSION:
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Authors | J A Thorp, P G Jones, R H Clark, E Knox, J L Peabody |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 185
Issue 4
Pg. 859-62
(Oct 2001)
ISSN: 0002-9378 [Print] United States |
PMID | 11641666
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Birth Weight
- Cerebral Hemorrhage
(diagnosis, epidemiology)
- Cesarean Section
- Confidence Intervals
- Female
- Gestational Age
- Humans
- Incidence
- Infant Mortality
(trends)
- Infant, Newborn
- Infant, Premature
- Intensive Care Units, Neonatal
- Logistic Models
- Odds Ratio
- Pregnancy
- Retrospective Studies
- Risk Factors
- Severity of Illness Index
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