[Clinical evaluation of isopropyl unoprostone (Rescula), in the adjunctive treatment of primary open angle glaucoma].

Abstract

AIM:

To investigate the clinical characteristics of docosanoid derivative, isopropyl unoprostone in the treatment of primary open angle glaucoma (POAG).

MATERIAL AND METHODS:

In 17 patients (22 eyes) with POAG we analysed prospectively the effect of Rescula upon intraocular pressure, aqueous flare, pupil size, ocular signs and symptoms. Patients were followed up every 2 weeks for at least 8 weeks with complete ocular examination. Concomitant topical therapeutics were used in the study: 0.5% Timolol--group I (16 eyes), and 0.5% Timolol + 2% Dorzolamide--group II (6 eyes).

RESULTS:

Mean (+/- SD) pretreatment pressure was 24.7 +/- 4.3 mm Hg in group I and it was reduced by 3.7 mm Hg (13.5%) (p < 0.05) at the end of the follow up. In group I Rescula was very effective (delta T% > 25%) in 6/16 eyes (37.5%) and it was ineffective (delta T% < 10%) in the same number of eyes. In group II pretreatment pressure was 24.8 +/- 2.6 mm Hg and it was reduced by 2.6 mm Hg (10.6%) (p = 0.1). Rescula induced no elevation of the aqueous flare during the treatment. No effect on pupil size was observed, either. Eye stinging/conjunctival hyperaemia was noted in 2/17 patients and punctate epitheliopathy in 1 patient (5.9%) that caused discontinuation of drops.

CONCLUSIONS:

Unoprostone produced significant additive effect to Timolol. Thus, it may be a valuable option for adjunctive therapy. However, interindividual differences need to be considered, as in some patients the response was insignificant.

• Authors: T Zarnowski, P Kawa, J Jurkowska-Dudzińska, Z Zagórski
• Journal: Klinika oczna (Klin Oczna) Vol. 103 Issue 1 Pg. 13-5 ( 2001) ISSN: 0023-2157 [Print] Poland
• Vernacular Title: Ocena kliniczna izopropylo-unoprostonu (Rescula) w terapii skojarzonej jaskry prostej otwartego kata.
• PMID: 11605578 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antihypertensive Agents
• Sulfonamides
• Thiophenes
• isopropyl unoprostone
• Timolol
• dorzolamide
• Dinoprost

Topics

• Administration, Topical
• Antihypertensive Agents (administration & dosage, pharmacology, therapeutic use)
• Dinoprost (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• Drug Therapy, Combination
• Female
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Male
• Ocular Hypertension (drug therapy)
• Prospective Studies
• Sulfonamides (therapeutic use)
• Thiophenes (therapeutic use)
• Timolol (therapeutic use)