Abstract | OBJECTIVE AND DESIGN: SUBJECTS: Male Hartley guinea pigs were used. TREATMENT: Intranasally sensitized guinea pigs were challenged once every week for 13 weeks by inhalation of Japanese cedar pollen as the antigen. Dexamethasone and other agents were administered orally 3 and 1 h, respectively, before the 4th, 6th and 13th challenge. METHODS:
Sneezing frequency and the change in specific airway resistance (sRaw) were measured at these challenges. Two days after the 13th challenge, nasal responsiveness to histamine was evaluated by measuring sRaw after intranasal instillation of increasing doses of histamine. Moreover, the levels of TXB2, p-LTs and histamine were estimated in nasal cavity lavage fluid (NCLF) collected at the 13th challenge. RESULTS: Only terfenadine (10 mg/kg) significantly inhibited sneezing at any challenge time. Seratrodast (3 and 10 mg/ kg), pranlukast (30 mg/kg) and dexamethasone (10 mg/kg), but not terfenadine, suppressed both the early and late phase elevation of sRaw (biphasic nasal blockage), although the degree of inhibition on the early phase response varied with the challenge time. In contrast, the development of nasal hyperresponsiveness to histamine was inhibited by only dexamethasone. Furthermore, biphasic increases in TXB2, p-LTs and histamine in NCLF were observed after the challenge in sensitized animals. CONCLUSIONS:
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Authors | M Yamasaki, N Mizutani, K Sasaki, T Nabe, T Matsumoto, Y Ashida, S Kohno |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 50
Issue 9
Pg. 466-73
(Sep 2001)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 11603852
(Publication Type: Journal Article)
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Chemical References |
- Anti-Allergic Agents
- Anti-Asthmatic Agents
- Anti-Inflammatory Agents
- Benzoquinones
- Chromones
- Heptanoic Acids
- Leukotrienes
- seratrodast
- Thromboxane A2
- Terfenadine
- Dexamethasone
- Histamine
- pranlukast
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Topics |
- Animals
- Anti-Allergic Agents
(pharmacology)
- Anti-Asthmatic Agents
(pharmacology)
- Anti-Inflammatory Agents
(pharmacology)
- Benzoquinones
(pharmacology)
- Chromones
(pharmacology)
- Dexamethasone
(pharmacology)
- Guinea Pigs
- Heptanoic Acids
(pharmacology)
- Histamine
(pharmacology)
- Histamine Release
(drug effects)
- Leukotrienes
(physiology)
- Male
- Nasal Cavity
(pathology)
- Nasal Obstruction
(drug therapy, etiology, physiopathology)
- Rhinitis, Allergic, Seasonal
(drug therapy, physiopathology)
- Sneezing
- Terfenadine
(pharmacology)
- Therapeutic Irrigation
- Thromboxane A2
(physiology)
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