A study of intravaginal misoprostol for induction of labor in toxemia of pregnancy.

Abstract

OBJECTIVE:

To compare the efficacy and complications of intravaginal misoprostol for induction of labor in patients with and without toxemia of pregnancy.

METHODS:

Forty-two patients with toxemia of pregnancy (group 1) and 59 women at term without toxemia (group 2) with Bishop scores of < or = 6 were treated with 50 microg intravaginal misoprostol given four times at 4-h intervals. Labor and neonatal outcomes, and any complications, were recorded. Mann-Whitney U-, Student's t- and chi(2)-tests were used for statistical analyses. P < or = 0.05 was considered significant.

RESULTS:

The rates of vaginal delivery were 73.8% and 84.6%, oxytocin augmentation were 4.8% and 5.1% and the mean insertion to delivery times were 12.5 and 13.8 h in group 1 and 2, respectively, with no significant differences between the groups. Neonatal outcomes, rates of uterine contraction abnormalities and gastrointestinal symptoms were similar in both groups.

CONCLUSIONS:

Intravaginal misoprostol is an equally effective and safe method of induction of labor in patients with toxemia of pregnancy and in normal pregnant women.

• Authors: H G Sahin, H A Sahin, R Surucu, M Guvercinci
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 75 Issue 1 Pg. 3-9 (Oct 2001) ISSN: 0020-7292 [Print] United States
• PMID: 11597613 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Oxytocics
• Misoprostol

Topics

• Administration, Intravaginal
• Adult
• Female
• Gestational Age
• Humans
• Infant, Newborn
• Labor Stage, First (drug effects)
• Labor, Induced
• Misoprostol (administration & dosage, adverse effects, therapeutic use)
• Nausea (chemically induced)
• Obstetric Labor Complications (chemically induced)
• Oxytocics (administration & dosage, adverse effects, therapeutic use)
• Parity
• Pre-Eclampsia
• Pregnancy
• Pregnancy Outcome
• Uterine Contraction (drug effects)
• Vomiting (chemically induced)