Abstract | BACKGROUND: METHODS: RESULTS: A total of 198 medically treated patients with transient monocular blindness had a three-year risk of ipsilateral stroke that was approximately half of that among 417 medically treated patients with hemispheric transient ischemic attack (adjusted hazard ratio, 0.53; 95 percent confidence interval, 0.30 to 0.94). Six factors were associated with a higher risk of stroke in patients with monocular blindness--an age of 75 years or more, male sex, a history of hemispheric transient ischemic attack or stroke, a history of intermittent claudication, stenosis of 80 to 94 percent of the luminal diameter, and the absence of collateral circulation. The three-year risk of stroke with medical treatment for patients with zero or one risk factor was 1.8 percent, with two risk factors 12.3 percent, and with three or more risk factors 24.2 percent (P=0.003). The three-year absolute reduction in the risk of stroke associated with endarterectomy was -2.2 percent (i.e., a 2.2 percent increase in risk) among patients with zero or one risk factor, 4.9 percent among those with two risk factors, and 14.3 percent among those with three or more risk factors (P=0.23 by a test for interaction). CONCLUSIONS:
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Authors | O Benavente, M Eliasziw, J Y Streifler, A J Fox, H J Barnett, H Meldrum, North American Symptomatic Carotid Endarterectomy Trial Collaborators |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 345
Issue 15
Pg. 1084-90
(Oct 11 2001)
ISSN: 0028-4793 [Print] United States |
PMID | 11596587
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Aged
- Blindness
(etiology)
- Carotid Stenosis
(complications, drug therapy, surgery)
- Chi-Square Distribution
- Endarterectomy, Carotid
- Female
- Follow-Up Studies
- Humans
- Ischemic Attack, Transient
(etiology)
- Male
- Middle Aged
- Prognosis
- Proportional Hazards Models
- Stroke
(etiology, prevention & control)
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