Relevance of oral supplementation with antioxidants for prevention and treatment of skin disorders.

Abstract

Reactive oxygen species can cause harmful effects in keratinocytes and fibroblasts if antioxidative defence mechanisms are exhausted. Therefore, it seems to be reasonable to prove if oral supplementation with various nutrient antioxidants is useful in prevention or treatment of skin disorders especially in those mediated by UV irradiation. Betacarotene, ascorbic acid and tocopherol have been tested alone or in combination for prevention of sunburn, photodermatoses and photocarcinogenesis with divergent results. Other candidates for oral antioxidative supplementation in humans are selenium and polyphenols. However, clinical data are limited or missing up to date.

• Authors: B Tebbe
• Journal: Skin pharmacology and applied skin physiology (Skin Pharmacol Appl Skin Physiol) 2001 Sep-Oct Vol. 14 Issue 5 Pg. 296-302 ISSN: 1422-2868 [Print] Switzerland
• PMID: 11586071 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2001 S. Karger AG, Basel

Chemical References

• Antioxidants
• Phenols

Topics

• Animals
• Antioxidants (administration & dosage, therapeutic use)
• Dietary Supplements
• Humans
• Phenols (administration & dosage, therapeutic use)
• Skin Diseases (prevention & control)