Further studies on the mechanism of rise in blood pressure and tachycardia after intraventricular administration of aconitine.

Abstract

Intraventricular administration of aconitine nitrate (10 mug) consistently produced hypertension and tachycardia. Peripheral vaso-constriction due to increase in central vasomomotor tone mainly responsible for hypertension whereas stimulation of central beta-receptors with sympathoadr renal discharge responsible for tachycardia.

• Authors: B V Telang, B B Gaitonde, M S Kekre, G V Sukthankar
• Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol) 1975 Jan-Mar Vol. 19 Issue 1 Pg. 11-9 ISSN: 0019-5499 [Print] India
• PMID: 1158426 (Publication Type: Journal Article)

Chemical References

• Hydroxydopamines
• Phenoxybenzamine
• Atropine
• Reserpine
• Propranolol
• Aconitine
• Tetrabenazine

Topics

• Aconitine (administration & dosage, antagonists & inhibitors, pharmacology)
• Aconitum (analogs & derivatives)
• Adrenal Glands (physiology)
• Animals
• Atropine (pharmacology)
• Blood Pressure (drug effects)
• Cats
• Female
• Heart Rate (drug effects)
• Heart Ventricles
• Hydroxydopamines (pharmacology)
• Injections
• Male
• Phenoxybenzamine (pharmacology)
• Propranolol (pharmacology)
• Reserpine (pharmacology)
• Spinal Cord (physiology)
• Stimulation, Chemical
• Tetrabenazine (pharmacology)
• Vagus Nerve (physiology)