Effect of hyaluronic acid on corneal haze in a photorefractive keratectomy experimental model.

Abstract

PURPOSE:

To evaluate the ability of topical hyaluronic acid to decrease corneal opacity after excimer laser photorefractive keratectomy (PRK) in hens.

METHODS:

Twenty-four white hens underwent bilateral 193-nm excimer laser PRK to correct -9.00 D of myopia. One eye received postoperative treatment with topical 1% hyaluronic acid six times daily for 3 days; the other eye received phosphate buffered saline. Slit-lamp evaluation by a masked observer was performed for 6 months after PRK, and electron microscopy was carried out at the end of the study.

RESULTS:

There were no significant differences in postoperative haze between the eyes treated with hyaluronic acid and those treated with phosphate buffered saline.

CONCLUSION:

Topical administration of hyaluronic acid had no effect on the development of corneal haze following PRK in hens.

• Authors: S Gómez, J M Herreras, J Merayo, M García, P Argüeso, J Cuevas
• Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) (J Refract Surg) 2001 Sep-Oct Vol. 17 Issue 5 Pg. 549-54 ISSN: 1081-597X [Print] United States
• PMID: 11583225 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hyaluronic Acid

Topics

• Administration, Topical
• Animals
• Chickens
• Cornea (surgery, ultrastructure)
• Corneal Opacity (etiology, pathology, prevention & control)
• Disease Models, Animal
• Hyaluronic Acid (administration & dosage)
• Lasers, Excimer
• Myopia (pathology, surgery)
• Photorefractive Keratectomy (adverse effects)
• Wound Healing (drug effects)