Abstract | BACKGROUND/AIMS: Gram-positive bacterial DNA is frequently detectable in gallbladder bile of primary biliary cirrhosis (PBC) patients. To advance these findings, lipoteichoic acid (LTA) of gram-positive bacteria with high antigenicity was examined in liver specimens and bile from PBC patients and controls. METHODS: RESULTS: In the gallbladder bile, there was no significant difference in the positive rate of LTA between PBC and controls. LTA-containing mononuclear cells were frequently detected in the portal tracts, particularly around the bile ducts and in hepatic sinusoids in PBC, while they were infrequent or occasional in control livers. These LTA-containing cells were sinusoidal endothelial cells and Kupffer cells, and portal monocytes, which frequently expressed scavenger receptor class B type 1. CONCLUSIONS: LTA derived from bacterial fragments may reach the bile, not only in the diseased state but also under normal conditions. Such LTA may be involved in the development and progression of portal tract lesions, particularly bile duct lesions, in PBC.
|
Authors | K Tsuneyama, K Harada, N Kono, K Hiramatsu, Y Zen, Y Sudo, M E Gershwin, M Ikemoto, H Arai, Y Nakanuma |
Journal | Journal of hepatology
(J Hepatol)
Vol. 35
Issue 2
Pg. 156-63
(Aug 2001)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 11580136
(Publication Type: Journal Article)
|
Chemical References |
- CD36 Antigens
- Lipopolysaccharides
- Membrane Proteins
- Receptors, Immunologic
- Receptors, Lipoprotein
- Receptors, Scavenger
- SCARB1 protein, human
- Scarb1 protein, mouse
- Scavenger Receptors, Class B
- Teichoic Acids
- lipoteichoic acid
|
Topics |
- Adult
- Aged
- Bile
(metabolism)
- Bile Ducts, Intrahepatic
(metabolism, pathology)
- CD36 Antigens
(metabolism)
- Case-Control Studies
- Female
- Gram-Positive Bacteria
(metabolism, pathogenicity)
- Granuloma
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Lipopolysaccharides
(metabolism)
- Liver
(metabolism, pathology)
- Liver Cirrhosis, Biliary
(etiology, metabolism, pathology)
- Male
- Membrane Proteins
- Microscopy, Immunoelectron
- Middle Aged
- Receptors, Immunologic
- Receptors, Lipoprotein
- Receptors, Scavenger
- Scavenger Receptors, Class B
- Teichoic Acids
(metabolism)
|