Use of topical ketanserin for the treatment of ulcers in leprosy patients.

Abstract

A comparative study was carried out in which 66 leprosy patients with ulcers were randomly divided in two groups of 33 patients each: Group A (experimental group) was treated with ketanserin gel (2%) and group B with clioquinol cream and/or Lassar paste during a three month period. At the end of the study, when ulcer sizes in the two groups were compared, the group treated with topical ketanserin showed superior results (p < 0.001 using Kolmogorov-Smirnov's test). We conclude that the drug is useful as coadjuavant treatment for healing ulcers in these patients.

• Authors: J J Salazar, G G Serrano, G I Leon-Quintero, B M Torres-Mendoza
• Journal: Indian journal of leprosy (Indian J Lepr) 2001 Apr-Jun Vol. 73 Issue 2 Pg. 103-10 ISSN: 0254-9395 [Print] India
• PMID: 11579646 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Serotonin Antagonists
• Ketanserin

Topics

• Administration, Topical
• Adult
• Aged
• Female
• Humans
• Ketanserin (administration & dosage, therapeutic use)
• Leprosy (complications)
• Male
• Middle Aged
• Serotonin Antagonists (administration & dosage, therapeutic use)
• Skin Ulcer (drug therapy)
• Treatment Outcome