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Mebendazole (R 17635) in enterobiasis. A clinical trial in mental retardates.

Abstract
The efficacy of mebendazole against enterobiasis was tested on 150 institutionalized mental retardates (range 5-25 years). At the start of the trial all patients swallowed on tablet containing 100 mg mebendazole. Another tablet was administered to all patients 2 weeks and 1, 2 and 3 months later. 19 patients were further treated with one tablet 4 and 5 months after the start of the trial. The presence of E. vermicularis was checked with cellophane adhesive tapes from the anal skin and from the right-hand finger-tips before the trial and after 1, 3 and 6 months. 94 subjects were positive before the trial. At the first post-treatment examination, all patients were found negative. However, 12% were reinfected. No side effects were observed or reported.
AuthorsJ A Lormans, A J Wesel, O F Vanparus
JournalChemotherapy (Chemotherapy) Vol. 21 Issue 3-4 Pg. 255-60 ( 1975) ISSN: 0009-3157 [Print] SWITZERLAND
PMID1157575 (Publication Type: Journal Article)
Chemical References
  • Benzimidazoles
  • Mebendazole
Topics
  • Adolescent
  • Adult
  • Benzimidazoles (therapeutic use)
  • Child
  • Child, Preschool
  • Drug Evaluation
  • Enterobius (isolation & purification)
  • Female
  • Humans
  • Intellectual Disability
  • Male
  • Mebendazole (therapeutic use)
  • Oxyuriasis (drug therapy, microbiology)
  • Pregnancy
  • Recurrence
  • Time Factors

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