Management of postvitrectomy diabetic vitreous hemorrhage with tissue plasminogen activator (t-PA) and volume homeostatic fluid-fluid exchanger.

Abstract

The incidence of recurrent vitreous hemorrhage of proliferative diabetic retinopathy following posterior vitrectomy ranges from 29% to 75% in reported series. Fluid-gas exchange and vitreous cavity lavage are the popular methods of treating this kind of recurrent hemorrhage. The fluid-gas exchange cannot offer clear vision immediately after the procedure. To improve the function of the classic vitreous cavity lavage, we designed a volume homeostatic fluid-fluid exchanger - Chen's I/A device. Tissue plasminogen activator (t-PA) is a protease that preferentially converts fibrin-bound plasminogen to the active proteolytic enzyme, plasmin. It has been clinically and experimentally proven effective in lysis of postvitrectomy blood clot and fibrin formation. When the blood clot is formed in the vitreous cavity, intravitreal injection of t-PA can convert plasminogen to plasmin and remove the clot. From July 1999 to January 2000, ten eyes of postvitrectomy diabetic vitreous hemorrhage (PDVH) were collected. In each case, 4 days after intravitreal injection (IVI) of t-PA (30 microg), vitreous cavity lavage was performed with Chen's I/A device. Of these cases, 8 eyes (80%) experienced an immediate clearing of the vitreous cavity. Early complications included anterior hyaloid fibrovascular proliferation (2 eyes) and postoperative intraocular pressure elevation (3 eyes). On the basis of the results of this study, our conclusion is that volume homeostatic vitreous cavity lavage, combined with intravitreal injection of t-PA, is an excellent method for treatment of postvitrectomy diabetic vitreous hemorrhage but, in cases of PDVH with iris rubeosis, the advantage of this procedure is uncertain.

• Authors: W C Wu, S M Chang, J Y Chen, C W Chang
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 17 Issue 4 Pg. 363-71 (Aug 2001) ISSN: 1080-7683 [Print] United States
• PMID: 11572467 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• Plasminogen Activators
• Tissue Plasminogen Activator

Topics

• Aged
• Diabetic Retinopathy (drug therapy, etiology)
• Female
• Fibrinolytic Agents (therapeutic use)
• Fluid Therapy (instrumentation)
• Hemostatic Techniques (instrumentation)
• Humans
• Male
• Middle Aged
• Plasminogen Activators (therapeutic use)
• Recurrence
• Therapeutic Irrigation
• Tissue Plasminogen Activator (therapeutic use)
• Visual Acuity
• Vitrectomy (adverse effects)
• Vitreous Hemorrhage (drug therapy, etiology)