Genome-wide scan for Parkinson's disease: the GenePD Study.

Abstract

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

• Authors: A L DeStefano, L I Golbe, M H Mark, A M Lazzarini, N E Maher, M Saint-Hilaire, R G Feldman, M Guttman, R L Watts, O Suchowersky, A L Lafontaine, N Labelle, M F Lew, C H Waters, J H Growdon, C Singer, L J Currie, G F Wooten, P Vieregge, P P Pramstaller, C Klein, J P Hubble, M Stacy, E Montgomery, M E MacDonald, J F Gusella, R H Myers
• Journal: Neurology (Neurology) Vol. 57 Issue 6 Pg. 1124-6 (Sep 25 2001) ISSN: 0028-3878 [Print] United States
• PMID: 11571351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Genetic Markers
• Dopamine beta-Hydroxylase

Topics

• Aged
• Chromosomes, Human, Pair 1
• Chromosomes, Human, Pair 10
• Chromosomes, Human, Pair 16
• Chromosomes, Human, Pair 9
• Dopamine beta-Hydroxylase (genetics)
• Dystonia Musculorum Deformans (genetics)
• Genetic Linkage (genetics)
• Genetic Markers (genetics)
• Genetic Testing
• Genome
• Humans
• Male
• Middle Aged
• Parkinson Disease (diagnosis, genetics)