The regulation of the biosynthesis of ubiquinone in the rat.

Abstract

The urinary excretion of p-hydroxybenzoate was not altered by ubiquinone feeding, but, although decreased considerably, was not eliminated in protein deficiency. The incorporation of p-hydroxy[U-14C]benzaldehyde into ubiquinone in vivo increased in cold-exposed and p-chlorophenoxyisobutyrate (clofibrate)-fed rats, and these changes were parallel with the changes in the incorporation of [2-14C]mevalonate under these conditions. Starvation, cholesterol feeding and cholic acid feeding resulted in the decreased incorporation of p-hydroxy[U-14C]benzaldehyde into ubiquinone, confirming the decreased ubiquinone synthesis. Feeding exogenous ubiquinone increased the hepatic ubiquinone concentration, but did not cause any decrease in the incorporation of p-hydroxy[U-14C]benzaldehyde into ubiquinone, indicating the absence of a feedback control.

• Authors: S Ranganathan, T Ramasarma
• Journal: The Biochemical journal (Biochem J) Vol. 148 Issue 1 Pg. 35-9 (Apr 1975) ISSN: 0264-6021 [Print] England
• PMID: 1156398 (Publication Type: Journal Article)

Chemical References

• Benzaldehydes
• Hydroxybenzoates
• Ubiquinone
• Clofibrate
• Mevalonic Acid

Topics

• Animals
• Benzaldehydes (metabolism)
• Clofibrate (pharmacology)
• Cold Temperature
• Feedback
• Hydroxybenzoates (urine)
• In Vitro Techniques
• Liver (metabolism)
• Male
• Mevalonic Acid (metabolism)
• Protein Deficiency (metabolism)
• Rats
• Ubiquinone (biosynthesis)