HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Divergent effect of bacillus Calmette-Guérin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: implications for primate models in tuberculosis vaccine research.

Abstract
Despite the widespread use of bacillus Calmette-Guérin vaccination, Mycobacterium tuberculosis infection remains globally the leading cause of death from a single infectious disease. The complicated and often protracted dynamics of infection and disease make clinical trials to test new tuberculosis vaccines extremely complex. Preclinical selection of only the most promising candidates is therefore essential. Because macaque monkeys develop a disease very similar to humans, they have potential to provide important information in addition to small animal models. To assess the relative merits of rhesus and cynomolgus monkeys as screens for tuberculosis vaccines, we compared the efficacy of bacillus Calmette-Guérin vaccination and the course of infection in both species. Unvaccinated rhesus and cynomolgus monkeys both developed progressive disease with high levels of C-reactive protein, M. tuberculosis-specific IgG, and extensive pathology including cavitation and caseous necrosis. Bacillus Calmette-Guérin vaccination protected cynomolgus almost completely toward the development of pathology, reflected in a striking 2-log reduction in viable bacteria in the lungs compared with nonvaccinated animals. Rhesus, on the other hand, were not protected efficiently by the bacillus Calmette-Guérin. The vaccinated animals developed substantial pathology and had negligible reductions of colony-forming units in the lungs. Comparative studies in these closely related species are likely to provide insight into mechanisms involved in protection against tuberculosis.
AuthorsJ A Langermans, P Andersen, D van Soolingen, R A Vervenne, P A Frost, T van der Laan, L A van Pinxteren, J van den Hombergh, S Kroon, I Peekel, S Florquin, A W Thomas
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 98 Issue 20 Pg. 11497-502 (Sep 25 2001) ISSN: 0027-8424 [Print] United States
PMID11562492 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antibodies, Bacterial
  • BCG Vaccine
  • C-Reactive Protein
Topics
  • Animals
  • Antibodies, Bacterial (blood, immunology)
  • BCG Vaccine (administration & dosage, immunology)
  • C-Reactive Protein (metabolism)
  • Cells, Cultured
  • Disease Models, Animal
  • Drug Evaluation, Preclinical (methods)
  • Leukocytes, Mononuclear (immunology)
  • Macaca fascicularis (immunology)
  • Macaca mulatta (immunology)
  • Male
  • Mycobacterium tuberculosis (immunology)
  • Species Specificity
  • Tuberculosis (immunology, pathology, prevention & control, veterinary)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: