Comparison of once-daily versus twice-daily administration of cefdinir against typical bacterial respiratory tract pathogens.

Abstract

In an in vitro pharmacodynamic model, a twice-daily cefdinir dosing regimen was more effective than a once-daily regimen against common bacterial respiratory pathogens in producing 3-log(10) killing and preventing the occurrence of regrowth at 24 h. Twice-daily administration is likely the more appropriate cefdinir dosing strategy for the treatment of community-acquired pneumonia.

• Authors: G H Ross, L B Hovde, K H Ibrahim, Y H Ibrahim, J C Rotschafer
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 45 Issue 10 Pg. 2936-8 (Oct 2001) ISSN: 0066-4804 [Print] United States
• PMID: 11557496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• Cefdinir

Topics

• Anti-Bacterial Agents (administration & dosage, pharmacology)
• Cefdinir
• Cephalosporins (administration & dosage, pharmacology)
• Haemophilus influenzae (drug effects)
• Humans
• Microbial Sensitivity Tests
• Respiratory Tract Infections (microbiology)
• Streptococcus pneumoniae (drug effects)
• Streptococcus pyogenes (drug effects)