Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment.

Abstract

We demonstrated the effect of clonazepam (2 mg/day) on Meige syndrome in two schizophrenic patients under continuous treatment with antipsychotic drugs, and changes in the plasma levels of gamma-aminobutyric acid (GABA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in these cases. The plasma levels of HVA and MHPG during treatment with clonazepam were decreased in the responder, while not changed in the non-responder to clonazepam. A difference between the responder and the non-responder was not found in the plasma GABA levels. These results suggest that hyperactivities of the central dopaminergic and noradrenergic neurones are involved in the pathophysiology of Meige syndrome.

• Authors: R Yoshimura, S Kakihara, A Soya, N Ueda, K Shinkai, J Nakamura
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 55 Issue 5 Pg. 543-6 (Oct 2001) ISSN: 1323-1316 [Print] Australia
• PMID: 11555353 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antipsychotic Agents
• Methoxyhydroxyphenylglycol
• gamma-Aminobutyric Acid
• Clonazepam
• Homovanillic Acid

Topics

• Adult
• Antipsychotic Agents (adverse effects, therapeutic use)
• Clonazepam (adverse effects, therapeutic use)
• Female
• Homovanillic Acid (blood)
• Humans
• Meige Syndrome (blood, chemically induced, drug therapy)
• Methoxyhydroxyphenylglycol (blood)
• Schizophrenia, Disorganized (blood, drug therapy)
• Schizophrenia, Paranoid (blood, drug therapy)
• gamma-Aminobutyric Acid (blood)