Abstract | INTRODUCTION: Based on the fact that pancreatic carcinoma is still associated with poor outcome, the aim of the study was to determine frequency of early tumor cell dissemination using immunohistology in lymph nodes classified as tumor-free by conventional histopathology. METHODS: RESULTS: CONCLUSION: Detection of disseminated tumor cells in lymph nodes using an antibody against cytokeratin is specific and suitable while use of an antibody against CA19-9 is not recommendable because of the high rate of false-positive results. The results may indicate that ductal pancreatic carcinoma generates early dissemination of tumor cells into lymph nodes. This may be one explanation for the poor outcome of this carcinoma compared with that of the carcinoma of the papilla of Vater (14 versus 48 months P < 0.05).
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Authors | K Ridwelski, F Meyer, J Fahlke, U Kasper, A Roessner, H Lippert |
Journal | Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
(Chirurg)
Vol. 72
Issue 8
Pg. 920-6
(Aug 2001)
ISSN: 0009-4722 [Print] Germany |
Vernacular Title | Stellenwert von Cytokeratin- und CA19-9-Antigen im immunhistologischen Nachweis disseminierter Tumorzellen in Lymphknoten beim Pankreascarcinom. |
PMID | 11554137
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-19-9 Antigen
- Keratins
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Topics |
- Adenocarcinoma
(pathology)
- Adult
- Aged
- Ampulla of Vater
(pathology)
- Biomarkers, Tumor
(analysis)
- CA-19-9 Antigen
(analysis)
- Carcinoma
(pathology)
- Chronic Disease
- Common Bile Duct Neoplasms
(pathology)
- Female
- Humans
- Immunohistochemistry
- Keratins
(analysis)
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Pancreatic Neoplasms
(pathology)
- Pancreatitis
(pathology)
- Predictive Value of Tests
- Prognosis
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