Acute and 6-month clinical and angiographic outcome after implantation of the ACS Duet stent for single-vessel coronary artery disease: final results of the European and US ACS Multi-link Duet Registry.

Abstract

The aim of the study was to determine the safety and efficacy of the second-generation ACS Multi-Link Duet coronary stent system for the treatment of single, symptomatic, de novo, native coronary artery lesions. Between February and June 1998, 427 patients (69.3% male, 51.5% class 3 or 4 angina, 20.1% diabetic, 43.6% hyperlipidemia) were included at 38 centers in this prospective observational study. All patients received ticlopidine 500 mg/day for 1 month and aspirin > or =100 mg/day. The Duet stent was available in 8, 18, and 28 mm length and 3.0, 3.5, and 4.0 mm diameter. After adequate predilatation, stents were successfully implanted, at up to 16 atm, in 99.3% of patients. Mean vessel diameter by core laboratory quantitative coronary angiography was 3.0 +/- 0.53 mm and postprocedural minimum luminal diameter was 2.79 +/- 0.43 mm (12% +/- 9.3% diameter stenosis). At 30 days, 96.7% of patients were event-free and at 6 months 88.1% remained free of major adverse cardiac events. The restenosis rate was 18.1%. The ACS Duet stent was safely implanted in >99% of target lesions by a diverse group of international investigators. With late outcomes at least comparable to the best published results, this stent platform provides safe and effective percutaneous treatment of obstructive coronary artery disease. Cathet Cardiovasc Intervent 2001;54:25-33.

• Authors: D P Foley, D Kererakes, J A te Riele, N Nishimura, S Veldhof, S Fink, A Yeung, D van Hoogenhuyze, A M Lansky, G A van Es, M J Kutryk, P W Serruys, US and European Duet Investigators
• Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (Catheter Cardiovasc Interv) Vol. 54 Issue 1 Pg. 25-33 (Sep 2001) ISSN: 1522-1946 [Print] United States
• PMID: 11553944 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Topics

• Aged
• Angioplasty, Balloon, Coronary (instrumentation)
• Coronary Angiography
• Coronary Disease (diagnostic imaging, mortality, therapy)
• Endpoint Determination
• Equipment Design
• Europe
• Female
• Humans
• Length of Stay
• Male
• Middle Aged
• Prospective Studies
• Prosthesis Implantation (instrumentation)
• Registries
• Stents
• Survival Analysis
• Time Factors
• Treatment Outcome
• United States