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Collagen implant for treating stress urinary incontinence in women with urethral hypermobility.

AbstractPURPOSE:
We evaluated the use of collagen in women with stress urinary incontinence and urethral hypermobility.
MATERIALS AND METHODS:
We treated 90 patients with stress urinary incontinence and urethral hypermobility with 1 to 3 injections of Contigen implant (C. R. Bard, Inc., Covington, Georgia) between June 1996 and October 1998. Observations at 3, 6 and 12 months included continence grade, 7-day voiding diaries and quality of life questionnaires. Abdominal leak point pressure was determined at baseline and 12 months.
RESULTS:
At the 6-month followup 68 patients remained in the study, of whom 30 (44%) were dry and 24 (35%) were improved. Of the 58 patients who reached the 12-month followup 19 (33%) were dry and 19 (33%) were improved. Considering all patients entered into the study at 6 months 30 (33%) were dry and 24 (27%) were improved. Of the original 90 patients 19 (21%) were dry and 19 (21%) were improved at 12 months. The probability of maintaining initial improvement for 12 months was 44%. The success of bulking agent therapy was not predicted by the initial incontinence grade. Improved continence grade correlated with improved leak point pressure.
CONCLUSIONS:
This therapy is appropriate in women with urethral hypermobility who wish to avoid surgical risks and in those in whom surgery is ill advised.
AuthorsA E Bent, J Foote, S Siegel, G Faerber, R Chao, E A Gormley
JournalThe Journal of urology (J Urol) Vol. 166 Issue 4 Pg. 1354-7 (Oct 2001) ISSN: 0022-5347 [Print] United States
PMID11547073 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • glutaraldehyde-cross-linked collagen
  • Collagen
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Collagen
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Prospective Studies
  • Prostheses and Implants
  • Urethral Diseases (complications)
  • Urinary Incontinence, Stress (etiology, therapy)

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