Abstract | OBJECTIVE: DESIGN: Prospective animal trial followed by a controlled cell culture study. SETTING: Laboratory of the Department of Anesthesiology. SUBJECTS: Male Sprague-Dawley rats weighing 200-250 g, PC12 cell line. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: These findings show that in our model of sepsis, the expression of AT2 receptors in the adrenal gland is down-regulated in a nitric oxide-dependent manner. Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system.
|
Authors | M Bucher, J Hobbhahn, A Kurtz |
Journal | Critical care medicine
(Crit Care Med)
Vol. 29
Issue 9
Pg. 1750-5
(Sep 2001)
ISSN: 0090-3493 [Print] United States |
PMID | 11546977
(Publication Type: Journal Article)
|
Chemical References |
- Cytokines
- Lipopolysaccharides
- Receptors, Angiotensin
- Nitric Oxide
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
|
Topics |
- Adrenal Glands
(drug effects, metabolism)
- Animals
- Cells, Cultured
- Cytokines
(pharmacology)
- Down-Regulation
- Lipopolysaccharides
- Male
- Nitric Oxide
(pharmacology)
- Nitric Oxide Synthase
(pharmacology)
- Nitric Oxide Synthase Type II
- Rats
- Rats, Sprague-Dawley
- Receptors, Angiotensin
(drug effects)
- Sepsis
(metabolism)
|