Abstract |
Scant data are available concerning the impact and response to therapy of respiratory syncytial virus ( RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal.
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Authors | S Ghosh, R E Champlin, N T Ueno, P Anderlini, K Rolston, I Raad, D Kontoyiannis, K Jacobson, M Luna, J Tarrand, E Whimbey |
Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 28
Issue 3
Pg. 271-5
(Aug 2001)
ISSN: 0268-3369 [Print] England |
PMID | 11535995
(Publication Type: Journal Article)
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Chemical References |
- Aerosols
- Antiviral Agents
- Immunoglobulins, Intravenous
- Ribavirin
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Topics |
- Aerosols
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, toxicity)
- Antiviral Agents
(administration & dosage)
- Bone Marrow Transplantation
(adverse effects, mortality)
- Breast Neoplasms
(complications, therapy)
- Disease Progression
- Female
- Hematopoietic Stem Cell Transplantation
(adverse effects, mortality)
- Humans
- Immunoglobulins, Intravenous
(administration & dosage)
- Pneumonia, Viral
(chemically induced, drug therapy, mortality)
- Respiratory Syncytial Virus Infections
(chemically induced, drug therapy, mortality)
- Retrospective Studies
- Ribavirin
(administration & dosage)
- Survival Rate
- Transplantation, Autologous
(adverse effects, mortality)
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