Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions.

Abstract

A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.

• Authors: E J Pretell, H H García, R H Gilman, H Saavedra, M Martinez, Cysticercosis Working Group in Peru
• Journal: Clinical neurology and neurosurgery (Clin Neurol Neurosurg) Vol. 103 Issue 3 Pg. 175-7 (Oct 2001) ISSN: 0303-8467 [Print] Netherlands
• PMID: 11532559 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anthelmintics
• Praziquantel

Topics

• Adult
• Animals
• Anthelmintics (therapeutic use)
• Brain Diseases (diagnostic imaging, drug therapy)
• Cysticercus (drug effects)
• Female
• Humans
• Male
• Middle Aged
• Neurocysticercosis (diagnostic imaging, drug therapy)
• Praziquantel (therapeutic use)
• Tomography, X-Ray Computed
• Treatment Failure
• Treatment Outcome