Abstract | BACKGROUND: Topical immunotherapy with a contact allergen is effective in alopecia areata (AA). However, the mechanism of the effect is still unknown, and pretreatment prediction of the outcome of therapy in each patient remains difficult. OBJECTIVES: To predict the clinical effect of this therapy in AA patients, we investigated the relationship between clinical responses to topical immunotherapy and in vitro proliferative responses of peripheral blood mononuclear cells (PBMC) to T-cell stimulants. METHODS: RESULTS: PBMC from the AA patients with a good clinical response to immunotherapy showed a normal level of proliferation, whereas PBMC from the poor responders showed a markedly suppressed proliferative response and interleukin (IL)-2 production, but increased IL-4 production compared with the controls. CONCLUSIONS: The proliferative response of PBMC to T-cell stimulants may be one of the indicators of the clinical effect of topical immunotherapy for AA.
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Authors | T Yoshino, H Asada, Y Ando, H Fujii, Y Yamaguchi, K Yoshikawa, S Itami |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 145
Issue 3
Pg. 415-21
(Sep 2001)
ISSN: 0007-0963 [Print] England |
PMID | 11531830
(Publication Type: Journal Article)
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Chemical References |
- Allergens
- Cyclopropanes
- Cytokines
- Enterotoxins
- Phytohemagglutinins
- enterotoxin B, staphylococcal
- diphenylcyclopropenone
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Topics |
- Adolescent
- Adult
- Allergens
(therapeutic use)
- Alopecia Areata
(immunology, therapy)
- Cell Culture Techniques
- Cell Division
(immunology)
- Child
- Cyclopropanes
(immunology)
- Cytokines
(biosynthesis)
- Enterotoxins
(immunology)
- Female
- Humans
- Immune Tolerance
- Immunotherapy
(methods)
- Male
- Middle Aged
- Phytohemagglutinins
(immunology)
- Prognosis
- T-Lymphocytes
(immunology)
- Treatment Outcome
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