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[A case of Churg-Strauss syndrome in which positive rheumatoid factor and MPO-ANCA preceded the development of clinical symptoms of vasculitis].

Abstract
A 52-year-old man in whom bronchial asthma had been diagnosed in 1995 was admitted for the treatment of Churg-Strauss syndrome in June 1997. Positive tests MPO-ANCA and rheumatoid factor preceded the symptoms of vasculitis for several months. A skin biopsy revealed infiltration of eosinophils in the vessel walls, and the diagnosis of Churg-Strauss syndrome was confirmed. After systemic administration of corticosteroids, the symptoms other than mononeuritis improved markedly, and his MPO-ANCA and rheumatoid factor became negative. Rheumatoid factor and MPO-ANCA may be useful for the early diagnosis of Churg-Strauss syndrome in patients with bronchial asthma in which a well-controlled disease develops into an intractable condition.
AuthorsM Furuiye, K Konno, Y Sumi, Y Ohtani, M Sawada, T Umino, N Inase, S Miyake, Y Yoshizawa
JournalNihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 39 Issue 6 Pg. 410-4 (Jun 2001) ISSN: 1343-3490 [Print] Japan
PMID11530389 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antibodies, Antineutrophil Cytoplasmic
  • Biomarkers
  • Rheumatoid Factor
  • Prednisolone
  • Peroxidase
Topics
  • Antibodies, Antineutrophil Cytoplasmic (blood)
  • Biomarkers (blood)
  • Churg-Strauss Syndrome (diagnosis, drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Peroxidase (immunology)
  • Prednisolone (administration & dosage)
  • Rheumatoid Factor (blood)
  • Time Factors

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