Pituitary apoplexy caused by luteinizing hormone-releasing hormone in prolactin-producing adenoma.

Abstract

We report a case in which pituitary apoplexy developed shortly after an intravenous (i.v.) injection of luteinizing hormone-releasing hormone (LH-RH). A 56-year-old man with prolactin-producing pituitary tumor complained of severe headache, visual field loss and facial nerve palsy shortly after LH-RH test. Magnetic resonance image (MRI) revealed a hemorrhage in the pituitary adenoma. He showed dramatic improvement in his symptoms after decompression surgery. These findings suggest a causal relationship between the i.v. injection of LH-RH and pituitary apoplexy. Possible pituitary apoplexy should be kept in mind during pituitary testing.

• Authors: N Hiroi, T Ichijo, M Shimojo, H Ueshiba, K Tsuboi, Y Miyachi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 40 Issue 8 Pg. 747-50 (Aug 2001) ISSN: 0918-2918 [Print] Japan
• PMID: 11518116 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gonadotropins, Pituitary
• Hormones
• Gonadotropin-Releasing Hormone

Topics

• Facial Paralysis (etiology)
• Gonadotropin-Releasing Hormone (administration & dosage, adverse effects)
• Gonadotropins, Pituitary
• Headache (etiology)
• Hormones (blood)
• Humans
• Injections, Intravenous
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Pituitary Apoplexy (blood, chemically induced, complications, diagnosis)
• Pituitary Neoplasms (diagnosis)
• Prolactinoma (diagnosis)
• Vision Disorders (etiology)