Generalized Wegener's granulomatosis responding to sulfamethoxazole-trimethoprim monotherapy.

Abstract

Wegener's granulomatosis (WG) has two different clinical phases: the initial phase and generalized phase. In patients with generalized WG, both steroids and cyclophosphamide have generally been used. We report a case of generalized WG that was temporarily, but successfully treated with sulfamethoxazole-trimethoprim (S/T) alone. S/T therapy reduced the elevated levels of soluble IL-2 receptor and IL-6 in parallel with improvement of the patient's symptoms and urinary protein excretion. In view of the high incidence of lethal adverse effects of cytotoxic drugs, S/T monotherapy may be worth trying not only for initial phase WG but also for generalized WG with careful follow-up when the patient is not acutely ill.

• Authors: T Ohtake, S Kobayashi, Y Honjou, T Shirai, S Takayanagi, K Tohyama, Y Tokura, M Kimura
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 40 Issue 7 Pg. 666-70 (Jul 2001) ISSN: 0918-2918 [Print] Japan
• PMID: 11506314 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents
• Cytokines
• Drug Combinations
• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Aged
• Anti-Infective Agents (therapeutic use)
• Cytokines (blood)
• Drug Combinations
• Female
• Granulomatosis with Polyangiitis (blood, drug therapy)
• Humans
• Remission Induction
• Treatment Outcome
• Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)