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Reduced prevalence of serum antibodies against adeno-associated virus type 2 in patients with adult T-cell leukaemia lymphoma.

Abstract
Seroepidemiological studies have shown previously that cancer patients are less likely to have antibodies against the tumour suppressive adeno-associated virus (AAV) than control groups. To examine the influence of AAV infection on the development of adult T-cell leukaemia lymphoma (ATLL), an endemic disease in Southern Japan that is caused by infection with the human T-cell leukaemia virus type 1 (HTLV-I), the prevalence of serum antibodies to AAV type 2 (AAV-2) was tested in healthy HTLV-I carriers (n = 39) and patients with ATLL (n = 31). The results showed a significant difference in AAV-2 seropositivity between the two groups: Only 29% of the ATLL patients had IgG antibodies against AAV-2, whereas 84.6% of the healthy HTLV-I carriers were seropositive. Analysis of total serum IgG and antibodies against the Epstein-Barr virus (EBV) EBNA1 antigen showed that the lack of AAV antibodies in patients was not due to an ATLL-associated immune deficiency. The lower level of AAV-2 seropositivity in ATLL-patients may indicate that AAV-2 antibody-positive HTLV-I carriers might be less likely to develop ATLL or that loss of AAV-2 antibodies may parallel the development of disease.
AuthorsC M Walz, M Nakamura, T Fukunaga, Y Jasiewicz, L Edler, J R Schlehofer, Y Tanaka
JournalJournal of medical virology (J Med Virol) Vol. 65 Issue 1 Pg. 185-9 (Sep 2001) ISSN: 0146-6615 [Print] United States
PMID11505462 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2001 Wiley-Liss, Inc.
Chemical References
  • Antibodies, Viral
  • Immunoglobulin G
Topics
  • Antibodies, Viral (blood)
  • Carrier State
  • Dependovirus (immunology)
  • Female
  • Human T-lymphotropic virus 1 (immunology)
  • Humans
  • Immunoglobulin G (blood)
  • Leukemia-Lymphoma, Adult T-Cell (immunology, virology)
  • Male
  • Parvoviridae Infections (epidemiology, immunology, virology)
  • Prevalence
  • Seroepidemiologic Studies

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