Abstract | BACKGROUND: METHODS: The authors reviewed the medical records of 22 patients who had received a histologic diagnosis of Castleman disease at the University of Texas M. D. Anderson Cancer Center between 1988 and 1999. One patient with a concurrent histopathologic diagnosis of nonsecretory multiple myeloma was excluded from the study. In all patients, the diagnosis of Castleman disease was based on the results of lymph node biopsies. Disease was categorized as being either unicentric or multicentric and further subdivided into hyaline vascular, plasma cell, or mixed variant histologic types. Clinical variables and outcomes were analyzed according to treatment, which consisted of surgery, chemotherapy, or radiotherapy. RESULTS: Records from 21 patients were analyzed: 12 had unicentric disease, and 9 had multicentric disease. The mean follow-up time for the entire series was 51 months (median, 40 months). Four patients with unicentric disease were treated with radiotherapy alone: 2 remain alive and symptom free, 2 died of causes unrelated to Castleman disease and had no evidence of disease at last follow-up. Eight patients with unicentric disease were treated with complete or partial surgical resection, and all are alive and asymptomatic. All nine patients with multicentric disease were treated with combination chemotherapy: five are alive with no evidence of disease, and four are alive with progressive disease. CONCLUSIONS:
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Authors | G M Chronowski, C S Ha, R B Wilder, F Cabanillas, J Manning, J D Cox |
Journal | Cancer
(Cancer)
Vol. 92
Issue 3
Pg. 670-6
(Aug 01 2001)
ISSN: 0008-543X [Print] United States |
PMID | 11505414
(Publication Type: Journal Article)
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Copyright | Copyright 2001 American Cancer Society. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Castleman Disease
(classification, radiotherapy, surgery)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Treatment Outcome
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