The effect of methimazole pretreatment on the efficacy of radioactive iodine therapy in Graves' hyperthyroidism: one-year follow-up of a prospective, randomized study.

The effect of antithyroid drugs on the efficacy of radioiodine (131I) treatment is still controversial. This study evaluated the effect of methimazole pretreatment on the efficacy of 131I therapy in Graves' hyperthyroidism. Sixty-one untreated patients were randomly assigned to receive 131I alone (32 patients) or 131I plus pretreatment with methimazole (30 mg/d; 29 patients). 131I was administered 4 d after drug discontinuation. The calculated 131I dose was 200 microCi/g thyroid tissue as estimated by ultrasound, corrected by 24-h radioiodine uptake. Serum TSH, T4, and free T4 were measured 4 d before 131I therapy, on the day of treatment, and then monthly for 1 yr. Considering cure as euthyroidism or hypothyroidism, based on free T4 measurement, approximately 80% of patients from both groups were cured 3 months after beginning 131I treatment. After 1 yr the groups were similar in terms of persistent hyperthyroidism (15.6% vs. 13.8%), euthyroidism (28.1% vs. 31.0%), or hypothyroidism (56.3% vs. 55.2%). Relapsed patients presented larger thyroid volume (P = 0.002), higher 24-h radioiodine uptake (P = 0.022), and T3 levels (P = 0.002). Multiple logistic regression analysis identified T3 values as an independent predictor of therapy failure. In conclusion, pretreatment with methimazole had no effect on either the time required for cure or the 1-yr success rate of 131I therapy.
AuthorsV A Andrade, J L Gross, A L Maia
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 86 Issue 8 Pg. 3488-93 (Aug 2001) ISSN: 0021-972X [Print] United States
PMID11502768 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antithyroid Agents
  • Iodine Radioisotopes
  • Triiodothyronine
  • Methimazole
  • Thyroxine
  • Adult
  • Antithyroid Agents (therapeutic use)
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Graves Disease (drug therapy, radiotherapy)
  • Humans
  • Hyperthyroidism (drug therapy, radiotherapy)
  • Iodine Radioisotopes (therapeutic use)
  • Male
  • Methimazole (therapeutic use)
  • Prospective Studies
  • Radiotherapy Dosage
  • Regression Analysis
  • Thyroid Gland (anatomy & histology, radiation effects)
  • Thyroxine (blood)
  • Time Factors
  • Triiodothyronine (blood)

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