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[Prevalence of cervical and cerebral atherosclerosis and silent brain infarction in patients with multivessel coronary artery disease].

AbstractOBJECTIVES:
This clinical study investigated the prevalence of cervical and cerebral atherosclerosis and silent brain infarction in patients with coronary artery disease.
METHODS:
Cervical and cerebral magnetic resonance angiography(MRA) was performed in 133 patients (98 males, 35 females, mean age 65.3 years) with suspected coronary artery disease, who were divided into a zero- and one-vessel disease group(n = 71) and a two- and three-vessel disease group(n = 62) depending on the number of major coronary branches with 75% or more stenosis. The MRA lesion was defined as more than 50% stenosis. Magnetic resonance imaging(MRI) of the brain was performed within 1 week of MRA in 78 patients without symptomatic stroke and atrial fibrillation. Silent brain infarction on MRI was defined as a focal high intensity area on T2-weighted images larger than 3 mm.
RESULTS:
The prevalence of MRA lesions was significantly greater in the two- and three-vessel group than in the zero- and one-vessel group(53% vs 14%, p < 0.01). The prevalence of MRI lesion was significantly higher in the two- and three-vessel group than in the zero- and one-vessel group(77% vs 36%, p < 0.01). The size and number of the MRI lesions were also significantly greater in the two- and three-vessel group than in the zero- and one-vessel group(p < 0.01). Neither age nor percentage of male gender was different between the groups. Diabetes mellitus was the common risk factor for coronary artery disease, MRA lesion and MRI lesion.
CONCLUSIONS:
Cervical and cerebral atherosclerosis and silent brain infarction are frequently observed in patients with multivessel coronary artery disease.
AuthorsK Uekita, N Funayama, T Nishiura, N Makiguchi, N Sakamoto, H Aoyama, R Kataoka, N Hasebe, K Kikuchi
JournalJournal of cardiology (J Cardiol) Vol. 38 Issue 1 Pg. 13-20 (Jul 2001) ISSN: 0914-5087 [Print] Netherlands
PMID11496431 (Publication Type: English Abstract, Journal Article)
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Arteriosclerosis (complications)
  • Carotid Artery Diseases (complications)
  • Cerebral Infarction (complications)
  • Coronary Disease (complications)
  • Female
  • Humans
  • Intracranial Arteriosclerosis (complications)
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Prevalence

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