Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: relationship with prognostic factors.

Abstract

We investigated the expression of mucin core proteins, Muc1, Muc2, and human gastric mucin (HGM) immunohistochemically in 5 non-invasive, 62 invasive ductal carcinomas and 3 mucinous carcinomas of the breast and statistically examined the relationship with prognostic factors. Muc1 was expressed in almost all breast carcinomas and there was a reverse correlation with tumor size (r = -0.25). However, Muc1 was not significantly correlated with the other tumor characteristics such as lymphocytic infiltration, axillary lymph node metastasis, TNM and plasma levels of CA153. Muc2 and HGM were expressed in 5 cases each in invasive ductal carcinomas, 0 and 3 in non-invasive ductal carcinomas, and 2 and 1 in mucinous carcinomas, respectively. Muc 2 expression correlated with lymph node metastasis. HGM was found in the tumors without lymph node metastasis and lower levels of serum CA153.

• Authors: Y Xu, N Kimura, R Yoshida, H Lin, K Yoshinaga
• Journal: Oncology reports (Oncol Rep) 2001 Sep-Oct Vol. 8 Issue 5 Pg. 1177-82 ISSN: 1021-335X [Print] Greece
• PMID: 11496338 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antigens, Neoplasm
• Biomarkers, Tumor
• Gastric Mucins
• MUC2 protein, human
• Mucin-1
• Mucin-2
• Mucins

Topics

• Adenocarcinoma, Mucinous (diagnosis, metabolism, mortality)
• Antibodies, Monoclonal
• Antigens, Neoplasm (metabolism)
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (diagnosis, metabolism, mortality)
• Carcinoma, Ductal, Breast (diagnosis, metabolism, mortality)
• Female
• Gastric Mucins (metabolism)
• Humans
• Immunoenzyme Techniques
• Middle Aged
• Mucin-1 (metabolism)
• Mucin-2
• Mucins (metabolism)
• Neoplasm Invasiveness
• Neoplasm Staging
• Prognosis
• Survival Rate