Abolished angiogenicity and tumorigenicity of rat glioma by 1-naphthalenemonosulfonate.

Abstract

Suramins and suradistas, an important group of potential anti-cancer agents, inhibit fibroblast growth factor (FGF) mitogenic activity. It has been shown that naphthalenesulfonates, with a common chemical function to the family of suramins and suradistas, mimic their inhibitory activity, abolishing FGF-induced angiogenesis in vivo, and inducing apoptosis of C6 glioma cells in culture. In the present report, we show that intratumoral administration of 1-naphthalenemonosulfonate induces a considerable regression of gliomas in rats, significantly enhances apoptosis, and attenuates tumor angiogenesis. These findings may lead to new approaches for the treatment of glioblastoma, a most common primary malignant brain tumor of very poor prognosis, as well as of other angiogenesis-dependent malignancies.

• Authors: P Cuevas, F Carceller, D Diaz, D Reimers, M Fernández, R M Lozano, R González-Corrochano, G Giménez-Gallego
• Journal: Neuroscience letters (Neurosci Lett) Vol. 308 Issue 3 Pg. 185-8 (Aug 10 2001) ISSN: 0304-3940 [Print] Ireland
• PMID: 11479019 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Naphthalenesulfonates
• 1-naphthalenesulfonic acid
• Fibroblast Growth Factors

Topics

• Angiogenesis Inhibitors (pharmacology)
• Animals
• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects)
• Brain Neoplasms (drug therapy)
• Fibroblast Growth Factors (physiology)
• Glioma (drug therapy)
• In Situ Nick-End Labeling
• Naphthalenesulfonates (pharmacology)
• Neoplasm Transplantation
• Neovascularization, Pathologic (drug therapy, physiopathology)
• Rats
• Rats, Sprague-Dawley
• Tumor Cells, Cultured (transplantation)