Flavonoids protect mice from two types of lethal shock induced by endotoxin.

Abstract

The protective effect of flavonoids on two types of lethal endotoxic shock was studied. A lethal endotoxic shock was induced by administration of lipopolysaccharide (LPS) into D-galactosamine (D-GalN)-sensitized mice and another one was done by administration of a high dose of LPS into normal mice. Pretreatment with a series of flavonoids protected mice from two types of endotoxin lethality. Flavonoid pretreatment reduced the serum tumor necrosis factor-alpha (TNF-alpha) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS. TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality. On the other hand, flavonoids reduced the plasma level of lipid peroxides in mice injected with a high dose of LPS, but not in D-GalN-sensitized mice. Taken together, these results indicated that flavonoids might protect mice from two types of endotoxin lethality. The protective mechanism of flavonoids in each endotoxin lethality is discussed.

• Authors: K Takahashi, A Morikawa, Y Kato, T Sugiyama, N Koide, M M Mu, T Yoshida, T Yokochi
• Journal: FEMS immunology and medical microbiology (FEMS Immunol Med Microbiol) Vol. 31 Issue 1 Pg. 29-33 (Jul 2001) ISSN: 0928-8244 [Print] England
• PMID: 11476978 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Flavonoids
• Lipid Peroxides
• Lipopolysaccharides
• Tumor Necrosis Factor-alpha
• Rutin
• Galactosamine

Topics

• Animals
• Dose-Response Relationship, Immunologic
• Female
• Flavonoids (therapeutic use)
• Galactosamine
• Immunization
• Injections, Intraperitoneal
• Lipid Peroxides (blood)
• Lipopolysaccharides
• Male
• Mice
• Mice, Inbred BALB C
• Rutin (therapeutic use)
• Shock, Septic (blood, chemically induced, prevention & control)
• Time Factors
• Tumor Necrosis Factor-alpha (analysis)