Neural cell adhesion molecule and neurothelin expression in human ameloblastoma.

Abstract	PURPOSE: The objective of the present study was to determine whether neural cell adhesion molecules (NCAM; CD56) and neurothelin (CD147) are expressed by adontogenic cells in the ameloblastoma. MATERIALS AND METHODS: Frozen sections from ameloblastoma specimens (n = 7) were stained with monoclonal antibody-recognizing CD56 and CD147 molecules using indirect immunoperoxidase and indirect immunofluorescent techniques. RESULTS: CD56 and CD147 molecules were strongly expressed by the peripheral columnar cells of the tumor nests. Neurothelin reactivity was also present in the stellate reticulum of the nests and in some stromal components. CONCLUSIONS: The presence of these antigens in ameloblastoma supports the classic view about the neural crest origin of cells giving use to this tumor.
Authors	N Er, A Dağdeviren, F Taşman, D Zeybek
Journal	Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 59 Issue 8 Pg. 900-3; discussion 904 (Aug 2001) ISSN: 0278-2391 [Print] United States
PMID	11474447 (Publication Type: Journal Article)
Copyright	Copyright 2001 American Association of Oral and Maxillofacial Surgeons
Chemical References	Antibodies, Monoclonal Antigens, CD Antigens, Neoplasm Antigens, Surface Avian Proteins BSG protein, human Blood Proteins Bsg protein, Gallus gallus Bsg protein, rat Coloring Agents Fluorescent Dyes Membrane Glycoproteins Neural Cell Adhesion Molecules Basigin Fluorescein-5-isothiocyanate Hematoxylin
Topics	Ameloblastoma (pathology) Antibodies, Monoclonal Antigens, CD Antigens, Neoplasm Antigens, Surface (analysis) Avian Proteins Basigin Blood Proteins Coloring Agents Fluorescein-5-isothiocyanate Fluorescent Antibody Technique, Indirect Fluorescent Dyes Hematoxylin Humans Immunoenzyme Techniques Jaw Neoplasms (pathology) Membrane Glycoproteins (analysis) Microscopy, Fluorescence Neural Cell Adhesion Molecules (analysis) Neural Crest (pathology)

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