Antiaggregation effect of alum on human platelets.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the effect of alum on human platelet aggregation.

METHODS:

Platelet-rich plasma fractions were prepared from fresh blood drawn from a group of healthy male volunteers. Platelet aggregation was induced by various inducers. The percent aggregation was recorded in the absence and presence of various concentrations of alum.

RESULTS:

Alum at concentrations less than 1.5 mg/ml inhibited platelet aggregation induced by collagen, epinephrine. ADP and thrombin in a dose-dependent manner. The IC50s were 0.668, 0.324, 0.250 and 0.191 mg/ml of alum, for collagen-, epinephrine-, ADP- and thrombin-induced platelet aggregation, respectively. In contrast, alum at concentrations up to 1.5 mg/ml did not inhibit ristocetin-induced platelet aggregation.

CONCLUSION:

Alum has an anti-platelet action and should be used cautiously in the treatment of intractable intravesical hemorrhage. Alum is a cheap anti-platelet drug that needs further investigation.

• Authors: F I Mohammed, Y A Shafagoj
• Journal: International journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther) Vol. 39 Issue 7 Pg. 322-4 (Jul 2001) ISSN: 0946-1965 [Print] Germany
• PMID: 11471777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Alum Compounds
• Platelet Aggregation Inhibitors
• aluminum sulfate

Topics

• Adjuvants, Immunologic (pharmacology)
• Adult
• Alum Compounds (pharmacology)
• Cell Culture Techniques
• Dose-Response Relationship, Drug
• Humans
• Male
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology)