[Effects of vitamin A supplementation on nutritional markers on the follow-up of malnutrition in children].

Abstract

Prospectively assessment of vitamin A supplemented during a follow-up of a protein-energy malnutrition rehabilitation included serum retinol, Retinol Binding Protein (RBP) and prealbumin (PA) determination. This study was conducted during one month on a group of 36 vitamin A (200,000 IU) supplemented malnourished children and 32 age-and sex-matched malnourished children receiving only a nutritional regimen. Determinations were carried out at days 0, 15 and 30. Protein marker concentrations increased steadily in supplemented children as compared to those in the untreated group (p < 0.05, Student's t test). On the other hand, serum concentrations of the two proteins progressively regained normal values in the vitamin A supplemented group. Data also showed that retinol supplementation in conjunction with an appropriate nutritional diet is effective in raising serum concentrations of vitamin A and its binding proteins to normal levels. Therefore, we concluded that the results of this study demonstrates the importance of vitamin A supplementation in the management of these deficiency states.

• Authors: M Ake, A G Poby, K A Malan, A Tebi, D Monnet
• Journal: Annales de biologie clinique (Ann Biol Clin (Paris)) 2001 Jul-Aug Vol. 59 Issue 4 Pg. 417-21 ISSN: 0003-3898 [Print] France
• Vernacular Title: Effets de la supplémentation en vitamine A sur les marqueurs de la nutrition dans la prise en charge de la malnutrition de l'enfant.
• PMID: 11470636 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Biomarkers
• Prealbumin
• Retinol-Binding Proteins
• Vitamin A

Topics

• Biomarkers (blood)
• Child, Preschool
• Dietary Supplements
• Female
• Follow-Up Studies
• Humans
• Infant
• Kwashiorkor (blood, complications, diet therapy, drug therapy)
• Male
• Nutrition Disorders (blood, diet therapy, drug therapy)
• Prealbumin (analysis, metabolism)
• Protein-Energy Malnutrition (blood, complications, diet therapy, drug therapy)
• Retinol-Binding Proteins (analysis, metabolism)
• Time Factors
• Vitamin A (blood, therapeutic use)