Discordance between cerebral oxygen and glucose metabolism, and hemodynamics in a mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode patient.

Abstract

A patient with mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode (MELAS) syndrome underwent serial measurement of cerebral blood flow with xenon computed tomography (Xe-CBF) while presenting with strokelike episodes accompanied by a cerebral lesion. He underwent positron emission tomography (PET) measurement of the regional cerebral blood flow (PET-CBF), metabolic rate of oxygen (CMRO2), and glucose (CMRGlu) after his symptoms and lesion disappeared. During the symptomatic period, Xe-CBF and the Xe-CBF response to acetazolamide loading were well preserved both in and outside the low-density lesion. In the PET study, decreased CMRO2 and increased PET-CBF and CMRGlu were noted in the entire brain. The strokelike episodes of patients with MELAS are more likely attributed to the failure of oxygen metabolism than to a vascular accident.

• Authors: T Nariai, K Ohno, Y Ohta, K Hirakawa, K Ishii, M Senda
• Journal: Journal of neuroimaging : official journal of the American Society of Neuroimaging (J Neuroimaging) Vol. 11 Issue 3 Pg. 325-9 (Jul 2001) ISSN: 1051-2284 [Print] United States
• PMID: 11462305 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Xenon
• Glucose
• Acetazolamide
• Oxygen

Topics

• Acetazolamide (administration & dosage)
• Adult
• Anticonvulsants (administration & dosage)
• Cerebrovascular Circulation
• Diagnosis, Differential
• Glucose (metabolism)
• Hemodynamics
• Humans
• MELAS Syndrome (diagnosis, metabolism)
• Magnetic Resonance Imaging
• Male
• Oxygen (metabolism)
• Tomography, Emission-Computed
• Tomography, X-Ray Computed (methods)
• Xenon