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Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide.

Abstract
A case of severe, transfusion dependent anaemia in a 72 year old woman, which on endoscopy was found to be due to gastric antral vascular ectasia (GAVE), is reported. Repeated endoscopic sclerotherapy was ineffective. She subsequently developed Raynaud's phenomenon and on further investigation was found to have classical systemic sclerosis with lung involvement. Treatment with pulses of intravenous methylprednisolone and cyclophosphamide resulted in significant improvement in her pulmonary function tests and skin score. Coincidentally, her haemoglobin stabilised and further endoscopic examinations were normal. This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.
AuthorsA R Lorenzi, A H Johnson, G Davies, A Gough
JournalAnnals of the rheumatic diseases (Ann Rheum Dis) Vol. 60 Issue 8 Pg. 796-8 (Aug 2001) ISSN: 0003-4967 [Print] England
PMID11454645 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • Cyclophosphamide
  • Methylprednisolone
Topics
  • Aged
  • Anemia, Iron-Deficiency (etiology)
  • Anti-Inflammatory Agents (administration & dosage)
  • Cyclophosphamide (administration & dosage)
  • Drug Therapy, Combination
  • Female
  • Gastric Antral Vascular Ectasia (complications, drug therapy)
  • Humans
  • Immunosuppressive Agents (administration & dosage)
  • Methylprednisolone (administration & dosage)
  • Pulse Therapy, Drug
  • Scleroderma, Systemic (complications, drug therapy)
  • Sclerotherapy
  • Treatment Outcome

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