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Steroid-induced hypertrophic cardiomyopathy following stem cell transplantation in a neonate: a case report.

Abstract
We report a case of severe left ventricular outflow tract obstruction complicating steroid therapy in an infant undergoing allogeneic transplant in the first few weeks of life for treatment of Krabbe's disease. While this complication is well known to those treating premature infants, it has not been reported in the stem cell transplant setting. For young infants undergoing allogeneic transplant who require steroid therapy, cardiac monitoring after 2--3 weeks of therapy is recommended.
AuthorsJ J Lesnik, G K Singh, I C Balfour, D A Wall
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 27 Issue 10 Pg. 1105-8 (May 2001) ISSN: 0268-3369 [Print] England
PMID11438829 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Methylprednisolone
Topics
  • Anti-Inflammatory Agents (administration & dosage, adverse effects)
  • Cardiomyopathy, Hypertrophic (chemically induced, prevention & control)
  • Electrocardiography
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Infant, Newborn
  • Leukodystrophy, Globoid Cell (complications, diagnosis, therapy)
  • Methylprednisolone (administration & dosage, adverse effects)
  • Pregnancy
  • Prenatal Diagnosis
  • Transplantation, Homologous
  • Ventricular Dysfunction, Left (etiology)

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