Abstract | PURPOSE: While detecting bladder cancer, bladder tumor markers demonstrate improved sensitivity compared with urinary cytology but the current limitation is the low specificity and positive predictive value, that is high false-positive rate. We examined the clinical categories of the false-positive results, established relative exclusion criteria, and recalculated the specificity and positive predictive value of this assay with these criteria. MATERIALS AND METHODS: A total of 608 patients considered at risk for bladder cancer presented to a urology clinic and submitted a single urine sample. Of the 608 patients 529 (87%) presented with de novo hematuria or chronic voiding symptoms without a diagnosis of bladder cancer. There were 79 (13.0%) patients being monitored with a known history of bladder cancer. Each urine sample was examined via cytology, urinalysis, culture and NMP22 protein assay. All patients underwent office cystoscopy, and transurethral resection and/or biopsy if a bladder tumor was suspected. RESULTS: Of the 608 patients 226 (37.2%) presented with microscopic hematuria, 143 (23.5%) with gross hematuria and 239 (39.3%) had chronic symptoms of urinary frequency or dysuria. There were 52 (8.6%) patients who had histologically confirmed bladder cancer. Of these 52 cancers NMP22 detected 46 (88.5%), whereas cytology identified only 16 (30.8%). When atypical cytology was considered positive, cytology detected 32 (61.5%) cases. In the 135 patients with increased NMP22 values the 46 identified tumors were accompanied by 89 false-positive values yielding a specificity of 83.9% and a positive predictive value of 34.1%. These false-positive results were divided into 6 clinical categories. Exclusion of these categories improved the specificity and positive predictive value of NMP22 to 99.2% and 92.0%, respectively, yielding results similar to urinary cytology (99.8% and 94.1%). CONCLUSIONS: Awareness and exclusion of the categories of false-positive results can increase the specificity and positive predictive value of NMP22, enhancing the clinical use of this urinary tumor marker.
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Authors | L E Ponsky, S Sharma, L Pandrangi, S Kedia, D Nelson, A Agarwal, C D Zippe |
Journal | The Journal of urology
(J Urol)
Vol. 166
Issue 1
Pg. 75-8
(Jul 2001)
ISSN: 0022-5347 [Print] United States |
PMID | 11435827
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Nuclear Proteins
- nuclear matrix protein 22
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Biopsy, Needle
- Female
- Humans
- Male
- Mass Screening
(methods)
- Middle Aged
- Monitoring, Physiologic
(methods)
- Nuclear Proteins
(analysis, urine)
- Predictive Value of Tests
- Probability
- Sensitivity and Specificity
- Urinary Bladder Neoplasms
(diagnosis, urine)
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