Treatment with beta-cyclodextrin of natural Cryptosporidium parvum infections in lambs under field conditions.
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| Abstract |
Following the unexpected activity of the excipient beta-cyclodextrin against experimental infection by Cryptosporidium parvum in suckling mice, its efficacy in the prevention and treatment of natural infections in lambs was evaluated under field conditions. Fifty-three crossbred neonatal lambs were randomly selected for the study. Treatment consisted of oral administration of an aqueous suspension of beta-cyclodextrin at a dose of 500 mg/kg of body weight. To test prophylactic efficacy, the suspension was administered at 1, 2 and 3 days of age. To evaluate therapeutic efficacy, the suspension was administered on each of the 3 days following onset of diarrhoea. Infection was monitored by daily examination of faecal samples, from birth to 30 days. The criteria studied in evaluating efficacy were: oocyst shedding, the presence of diarrhoea, and weight gain at 15 and 30 days. In the group that received prophylactic treatment with beta-cyclodextrin, there were no mortalities and, compared with control lambs, there was a decrease in the number of animals infected, a longer prepatent period and notable reduction in the patent period and the duration of diarrhoea. Therapeutic treatment also reduced the patent period and the severity of diarrhoea. beta-cyclodextrin was well tolerated by all of the treated animals.
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| Authors | J A Castro-Hermida, J Quílez-Cinca, F López-Bernad, C Sánchez-Acedo, F Freire-Santos, E Ares-Mazás |
| Journal | International journal for parasitology (Int J Parasitol) Vol. 31 Issue 10 Pg. 1134-7 (Aug 2001) ISSN: 0020-7519 [Print] England |
| PMID | 11429179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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