Hope for clomiphene citrate resistant ovaries.

Abstract

OBJECTIVE:

To assess the presentation, different surgical modalities and their outcome in the treatment of polycystic ovarian disease.

METHODS:

A retrospective study was carried out on 66 patients with polycystic ovarian disease. The majority of the cases had a history of infertility for at least 2 years and were known to be clomiphene citrate resistant in the Saudi German Hospital, Jeddah between 1994 and 1998 undergoing laparoscopic ovarian drilling.

RESULTS:

More than 80% of the patients were below 30 years of age. The majority of cases below 30 years had primary infertility. Irregular cycle was the main clinical presentation in 75% of cases; ovarian volume was more than 5.5cm3 in all of the cases. Diathermy drilling was carried out for 50 patients, laser for 12 patients and wedge resection for 4 patients. The follow-up treatment showed that pregnancy rate was 23%, 38% and 0% in the 3 groups. Cases that failed to conceive had significantly higher luteinizing hormone level.

CONCLUSION:

Laparoscopic ovarian drilling using diathermy or laser is effective during the induction of ovulation and increases the pregnancy rate in cases of polycystic ovarian disease resistant to clomiphene citrate.

• Authors: M N Abdul Salam, F H Hasanain, B K Greiew
• Journal: Saudi medical journal (Saudi Med J) Vol. 22 Issue 6 Pg. 508-11 (Jun 2001) ISSN: 0379-5284 [Print] Saudi Arabia
• PMID: 11426241 (Publication Type: Journal Article)

Chemical References

• Fertility Agents, Female
• Clomiphene

Topics

• Adult
• Clomiphene
• Electrocoagulation
• Female
• Fertility Agents, Female
• Humans
• Laparoscopy
• Laser Therapy
• Polycystic Ovary Syndrome (surgery)
• Pregnancy
• Pregnancy Rate
• Retrospective Studies
• Treatment Outcome