Abstract | STUDY OBJECTIVE: METHODS: We conducted a randomized, controlled crossover trial in human volunteers. Five healthy volunteers (mean age, 35 years; range, 29 to 43 years) were randomized to receive intravenous placebo (50 mL of normal saline solution) or 5 g of pyridoxine (50 mL) over 5 minutes. A peripheral intravenous catheter was established in each arm, and a heparinized venous blood sample was obtained for base deficit at baseline and 3, 6, 10, 20, and 30 minutes after infusion. After at least a 1-week washout period, the volunteers were assigned to the alternate arms of the experiments, thus acting as their own control subjects. Data were analyzed by using the 2-tailed paired t test, controlling for multiple comparisons. RESULTS: No difference was noted between groups at baseline. A statistically significant increased base deficit was noted after the pyridoxine infusion versus control at 3 to 20 minutes but not at 30 minutes (P =.1). Maximal mean increase in base deficit (2.74 mEq/L) was noted at 3 minutes. CONCLUSION: A transient increase in base deficit occurs after the infusion of 5 g of pyridoxine in normal volunteers.
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Authors | F Lovecchio, S C Curry, K A Graeme, K L Wallace, J Suchard |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 38
Issue 1
Pg. 62-4
(Jul 2001)
ISSN: 0196-0644 [Print] United States |
PMID | 11423814
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidotes
- Antitubercular Agents
- Pyridoxine
- Isoniazid
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Topics |
- Acidosis
(blood, chemically induced, diagnosis)
- Adult
- Antidotes
(adverse effects)
- Antitubercular Agents
(adverse effects)
- Blood Gas Analysis
- Cross-Over Studies
- Drug Monitoring
- Humans
- Infusions, Intravenous
- Isoniazid
(adverse effects)
- Pyridoxine
(adverse effects)
- Seizures
(chemically induced, drug therapy)
- Time Factors
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