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Incidence of drug-induced aggravation in benign epilepsy with centrotemporal spikes.

AbstractPURPOSE:
Benign epilepsy with centrotemporal spikes (BECTS) is characterized by an excellent prognosis. Drug therapy is necessary in only a minority of patients. Carbamazepine (CBZ) and phenobarbital (PB) have been reported to cause electroclinical aggravation in some cases. The incidence of drug-induced aggravation in BECTS has never been established.
METHODS:
We retrospectively studied 98 consecutive cases of BECTS, examined at the Centre Saint Paul between 1984 and 1999; 82 patients had received one or more treatments, often successively and in association.
RESULTS:
We found only one case of electroclinical aggravation with CBZ among 40 patients exposed to CBZ (35 in monotherapy, five in polytherapy). An additional case showed a marked EEG aggravation on CBZ + PB among 14 patients taking PB (nine with monotherapy and five with polytherapy), and PB was apparently responsible. No patient treated with valproate or benzodiazepines showed aggravation.
CONCLUSIONS:
Aggravation of BECTS caused by antiepileptic drugs happens only rarely. There is a minor risk of aggravation with CBZ and also probably with PB. Drug-induced aggravation may occur only during certain periods coinciding with spontaneous worsening of BECTS.
AuthorsD Corda, P Gelisse, P Genton, C Dravet, M Baldy-Moulinier
JournalEpilepsia (Epilepsia) Vol. 42 Issue 6 Pg. 754-9 (Jun 2001) ISSN: 0013-9580 [Print] United States
PMID11422331 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticonvulsants
  • Carbamazepine
  • Phenobarbital
Topics
  • Acute Disease
  • Adolescent
  • Anticonvulsants (adverse effects, therapeutic use)
  • Carbamazepine (adverse effects, therapeutic use)
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Electroencephalography (drug effects, statistics & numerical data)
  • Epilepsy, Rolandic (chemically induced, drug therapy, epidemiology)
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Phenobarbital (adverse effects, therapeutic use)
  • Retrospective Studies

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