Abstract | PURPOSE: METHODS: We retrospectively studied 98 consecutive cases of BECTS, examined at the Centre Saint Paul between 1984 and 1999; 82 patients had received one or more treatments, often successively and in association. RESULTS: We found only one case of electroclinical aggravation with CBZ among 40 patients exposed to CBZ (35 in monotherapy, five in polytherapy). An additional case showed a marked EEG aggravation on CBZ + PB among 14 patients taking PB (nine with monotherapy and five with polytherapy), and PB was apparently responsible. No patient treated with valproate or benzodiazepines showed aggravation. CONCLUSIONS: Aggravation of BECTS caused by antiepileptic drugs happens only rarely. There is a minor risk of aggravation with CBZ and also probably with PB. Drug-induced aggravation may occur only during certain periods coinciding with spontaneous worsening of BECTS.
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Authors | D Corda, P Gelisse, P Genton, C Dravet, M Baldy-Moulinier |
Journal | Epilepsia
(Epilepsia)
Vol. 42
Issue 6
Pg. 754-9
(Jun 2001)
ISSN: 0013-9580 [Print] United States |
PMID | 11422331
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anticonvulsants
- Carbamazepine
- Phenobarbital
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Topics |
- Acute Disease
- Adolescent
- Anticonvulsants
(adverse effects, therapeutic use)
- Carbamazepine
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Drug Administration Schedule
- Drug Therapy, Combination
- Electroencephalography
(drug effects, statistics & numerical data)
- Epilepsy, Rolandic
(chemically induced, drug therapy, epidemiology)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Phenobarbital
(adverse effects, therapeutic use)
- Retrospective Studies
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