Effects of recombinant granulocyte-colony stimulating factor administration during Mycobacterium avium infection in mice.
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| Abstract |
Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes. Here we evaluated a possible protective role of this molecule in a mouse model of mycobacterial infection. The administration of recombinant G-CSF promoted an extensive blood neutrophilia but failed to improve the course of Mycobacterium avium infection in C57Bl/6 or beige mice. G-CSF administration also failed to improve the efficacy of a triple chemotherapeutic regimen (clarithromycin + ethambutol + rifabutin). G-CSF treatment did not protect interleukin-10 gene disrupted mice infected with M. avium. Spleen cells from infected mice treated with G-CSF had a decreased priming for antigen-specific production of interferon gamma compared to control infected mice. Our data do not substantiate previous reports on the protective activity of G-CSF in antimycobacterial immunity using mouse models.
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| Authors | A S Gonçalves, R Appelberg |
| Journal | Clinical and experimental immunology (Clin Exp Immunol) Vol. 124 Issue 2 Pg. 239-47 (May 2001) ISSN: 0009-9104 [Print] England |
| PMID | 11422200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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